Jamie (played by Jake Gyllenhaal) grows out of his superficiality, his womanizing, and his need to win the approval of others through his charm.
Maggie (played by Anne Hathaway) grows out of her clever retorts and heart armor of easy sex to deny and drown out her anger and sadness with her early onset Parkinson's disease.
Set against the backdrop of the extremely powerful, ultra-competitive world of pharmaceutical companies and their global sales representatives, each of these characters acts as a catalyst to the other to open to love.
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